LY295427, A NOVEL HYPOCHOLESTEROLEMIC AGENT, ENHANCES [3H]25-HYDROXYCHOLESTEROL BINDING TO LIVER CYTOSOLIC PROTEINS

LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins

LY295427, (3 alpha,4 alpha,5 alpha)-4-(2-propenylcholestan-3-ol), acts through an unknown mechanism to derepress the transcription of the low density lipoprotein (LDL) receptor in the presence of 25-hydroxycholesterol (25-OH chol).Preincubation with Pickled LY295427 in Chinese hamster ovary (CHO) cells increased uptake of 25-OH chol in a time-depen

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Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": Evidence for clearance through microvasculature

Abstract Background Translocation of nanoparticles (NP) from the pulmonary airways into other pulmonary compartments or the systemic circulation is controversially discussed in the literature.In a Cleats previous study it was shown that titanium dioxide (TiO2) NP were "distributed in four lung compartments (air-filled spaces, epithelium/endothelium

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